Exosomes (CAP-2003)

CAP-2003 represents exosomes isolated from the company’s proprietary cardiosphere-derived cells
(CDCs), and is being developed as a next-generation therapeutic platform in regenerative medicine. Exosomes are nano-sized, membrane-enclosed vesicles, or “bubbles” that are secreted by cells and contain bioactive molecules, including proteins, RNAs and microRNAs. They act as messengers to regulate the functions of neighboring cells, and pre-clinical research has shown that exogenously-administered exosomes can direct or, in some cases, re-direct cellular activity, supporting their therapeutic potential. Their size, ease of crossing cell membranes, and ability to communicate in native cellular language makes them an exciting class of potential therapeutic agents. CAP-2003 consists of exosomes secreted by CDCs, and is believed to mediate many of the effects that are observed with these cells, including anti-inflammatory, anti-angiogenic, anti-apoptotic, and anti-fibrotic effects. Capricor is currently conducting pre-clinical studies to explore the possible therapeutic benefits that exosomes may possess, with a focus on ophthalmologic, dermatologic and oncologic disease. Capricor expects to initially develop CAP-2003 for ocular graft-versus-host disease.

CSMC has granted Capricor worldwide rights to its CDC Exosome technology under an exclusive license agreement with Cedars-Sinai Medical Center.

Publications

View a list of publications relating to Capricor’s exosome technology.