Publications

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With a clear focus on developing transformative therapies from bench to bedside, Capricor Therapeutics continues to drive forward preclinical and clinical research to investigate the products in its pipeline and their varied mechanism of actions.

View a list of current and archived publications related to Capricor’s research listed below according to investigational product.


CDCs (CAP-1002)


Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice


Isotta Chimenti, Rachel Ruckdeschel Smith, Tao-Sheng Li, Gary Gerstenblith, Elisa Messina, Alessandro Giacomello, and Eduardo Marbán


TCT-152 ALLogeneic Heart STem Cells To Achieve Myocardial Regeneration (ALLSTAR): The Six Month Phase I Safety Results.


Raj Makkar; Richard Schatz; Jay H. Traverse; Andrew Hamer; Katherine Beattie; Rachel R. Smith; Frances Kivel; Linda Marban; Eduardo Marban; Timothy D. Henry. J Am Coll Cardiol. 2014;64(11_S):. doi:10.1016/j.jacc.2014.07.18



Abstract 20536: ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration (ALLSTAR): the One Year Phase I Results.


Raj Makkar, Richard Schatz, Jay Traverse, Andrew Hamer, Katherine Beattie, Rachel R Smith, Francie Kivel, Linda Marbán, Eduardo Marbán, and Timothy D Henry.Circulation. 2014;130:A20536



Angiogenesis, cardiomyocyte proliferation and anti-fibrotic effects underlie structural preservation post-infarction by intramyocardially-injected cardiospheres.


Tseliou E, de Couto G, Terrovitis J, Sun B, Weixin L, Marbán L, Marbán E. PLoS One. 2014 Feb 18;9(2):e88590.

Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair.


Cheng K, Malliaras K, Smith RR, Shen D, Sun B, Blusztajn A, Xie Y, Ibrahim A, Aminzadeh MA, Liu W, Li TS, De Robertis MA, Marbán L, Czer LS, Trento A, Marbán E. JACC Heart Fail. 2014 Feb;2(1):49-61.

Moving beyond surrogate endpoints in cell therapy trials for heart disease.


Malliaras K, Marbán E. Stem Cells Transl Med. 2014 Jan;3(1):2-6.

Validation of contrast-enhanced magnetic resonance imaging to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction.


Malliaras K, Smith RR, Kanazawa H, Yee K, Seinfeld J, Tseliou E, Dawkins JF, Kreke M, Cheng K, Luthringer D, Ho CS, Blusztajn A, Valle I, Chowdhury S, Makkar RR, Dharmakumar R, Li D, Marbán L, Marbán E. Circulation. 2013 Dec 24;128(25):2764-75.

Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction).


Malliaras K, Makkar RR, Smith RR, Cheng K, Wu E, Bonow RO, Marbán L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marbán E. J Am Coll Cardiol. 2014 Jan 21;63(2):110-22.

Allogeneic cardiospheres safely boost cardiac function and attenuate adverse remodeling after myocardial infarction in immunologically mismatched rat strains.


Tseliou E, Pollan S, Malliaras K, Terrovitis J, Sun B, Galang G, Marbán L, Luthringer D, Marbán E. J Am Coll Cardiol. 2013 Mar 12;61(10):1108-19.

Cardiomyocyte Proliferation and Progenitor Cell Recruitment Underlie Therapeutic Regeneration after Myocardial Infarction in the Adult Mouse Heart


Malliaras K, Zhang Y, Seinfeld J, Galang G, Tseliou E, Cheng K, Sun B, Aminzadeh M, Marbán E. EMBO Mol Med. 2013 Feb;5(2):191-209.

Brief report: Mechanism of extravasation of infused stem cells.


Cheng K, Shen D, Xie Y, Cingolani E, Malliaras K, Marbán E. Stem Cells. 2012 Dec;30(12):2835-42.

Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel


Cheng K, Blusztajn A, Shen D, Li TS, Sun B, Galang G, Zarembinski TI, Prestwich GD, Marban E, Smith RR, Marban L. Biomaterials. 2012 Jul;33(21):5317-24.

Magnetic enhancement of cell retention, engraftment, and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion.


Cheng K, Malliaras K, Li TS, Sun B, Houde C, Galang G, Smith J, Matsushita N, Marbán E. Cell Transplant. 2012;21(6):1121-35.

Direct Comparison of Different Stem Cell Types and Subpopulations Reveals Superior Paracrine Potency and Myocardial Repair Efficacy With Cardiosphere-Derived Cells


Li TS, Cheng K, Malliaras K, Smith RR, Zhang Y, Sun B, Matsushita N, Blusztajn A, Terrovitis J, Kusuoka H, Marban L, Marban E. J Am Coll Cardiol. 2012 Mar 6;59(10):942-53.

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase I trial


Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marban L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marban E. Lancet. 2012 Mar 10;379(9819):895-904.

Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction.


Cheng K, Shen D, Smith J, Galang G, Sun B, Zhang J, Marbán E. Biomaterials. 2012 Apr;33(10):2872-9.

Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction.


Shen D, Cheng K, Marbán E. J Cell Mol Med. 2012 Sep;16(9):2112-6.

Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells.


Malliaras K, Li TS, Luthringer D, Terrovitis J, Cheng K, Chakravarty T, Galang G, Zhang Y, Schoenhoff F, Van Eyk J, Marbán L, Marbán E. Circulation. 2012 Jan 3;125(1):100-12.

Intrinsic cardiac origin of human cardiosphere-derived cells.


White AJ, Smith RR, Matsushita S, Chakravarty T, Czer LS, Burton K, Schwarz ER, Davis DR, Wang Q, Reinsmoen NL, Forrester JS, Marbán E, Makkar R. Eur Heart J. 2013 Jan;34(1):68-75.

Cardiac cell therapy: where we’ve been, where we are, and where we should be headed


Malliaras K, Marban E. Br Med Bull. 2011;98:161-85.

Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction.


Lee ST, White AJ, Matsushita S, Malliaras K, Steenbergen C, Zhang Y, Li TS, Terrovitis J, Yee K, Simsir S, Makkar R, Marbán E. J Am Coll Cardiol. 2011 Jan 25;57(4):455-65.

Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing their Enhanced Functional Potency for Myocardial Repair.


Li TS, Cheng K, Lee ST, Matsushita S, Davis D, Malliaras K, Zhang Y, Matsushita N, Ruckdeshel Smith R, Marban E. Stem Cells. 2010 Nov;28(11):2088-98.

Dedifferentiation and proliferation of mammalian cardiomyocytes


Zhang Y, Li TS, Lee ST, Wawrowsky KA, Cheng K, Galang G, Malliaras K, Abraham MR, Wang C, Marban E. PLoS One. 2010 Sep 3;5(9):e12559.

Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair


Li TS, Cheng K, Malliaras K, Matsushita N, Sun B, Marban L, Zhang Y, Marban E. Cardiovasc Res. 2010 Aug 21.

Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells.


Stem Cells. 2010 Jul;28(7):1178-85.

Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction


Cheng K, Li TS, Malliaras K, Davis DR, Zhang Y, Marban E. Circ Res. 2010 May 28;106(10):1570-81.

Human cardiospheres are a source of stem cells with cardiomyogenic potential.


Davis DR, Ruckdeschel Smith R, Marban E. Stem Cells. 2010 May;28(5):903-4.

Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies


Davis DR, Kizana E, Terrovitis J, Barth AS, Zhang Y, Smith RR, Miake J, Marban E. J Mol Cell Cardiol. 2010 Aug;49(2):312-21.

Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice


Chimenti I, Smith RR, Li TS, Gerstenblith G, Messina E, Giacomello A, Marban E. Circ Res. 2010 Mar 19;106(5):971-80.

Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery


Terrovitis J, Lautamäki R, Bonios M, Fox J, Engles JM, Yu J, Leppo MK, Pomper MG, Wahl RL, Seidel J, Tsui BM, Bengel FM, Abraham MR, Marban E. J Am Coll Cardiol. 2009 Oct 20;54(17):1619-26.

Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue


Davis DR, Zhang Y, Smith RR, Cheng K, Terrovitis J, Malliaras K, Li TS, White A, Makkar R, Marban E. PLoS One. 2009 Sep 25;4(9):e7195.

Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy


Johnston PV, Sasano T, Mills K, Evers R, Lee ST, Smith RR, Lardo AC, Lai S, Steenbergen C, Gerstenblith G, Lange R, Marban E. Circulation. 2009 Sep 22; 120(12):1075-83, 7 p following 1083. Epub 2009 Sep 8.

Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart.


Terrovitis J, Stuber M, Youssef A, Preece S, Leppo M, Kizana E, Schär M, Gerstenblith G, Weiss RG, Marbán E, Abraham MR. Circulation. 2008 Mar 25;117(12):1555-62.

Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens


Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, Giacomello A, Abraham MR, Marban E. Circulation. 2007 Feb 20;115(7):896-908. Epub 2007 Feb 5.

Isolation and expansion of adult cardiac stem cells from human and murine heart.


Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F, Salio M, Battaglia M, Latronico MV, Coletta M, Vivarelli E, Frati L, Cossu G, Giacomello A. Circ Res. 2004 Oct 29;95(9):911-21. Epub 2004 Oct 7.

Exosomes

Extracellular Vesicles


Macrophages Mediate Cardioprotective Cellular Postconditioning in Acute Myocardial Infarction


Geoffrey de Couto, Weixin Liu, Eleni Tseliou, Baiming Sun, Nupur Makkar, Hideaki Kanazawa,
Moshe Arditi, and Eduardo Marbán


Commercial Potential as Byproducts of Cell Manufacturing for Research and Therapeutic Use


James A. Smith, Kelvin S. Ng, Benjamin E. Mead, Sue Dopson, Brock Reeve, James Edwards, Matthew J.A. Wood, Andrew J. Carr, Kim Bure, Jeffrey M. Karp, and David A. Brindley

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy.


Ibrahim A, Cheng K, Marban E. Stem Cell Reports. 2014 May;2(5): 606-619.