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Exosomes: Scalable Production, Purification, and Characterization Methods using 293F Cells

Michael LeClaire, Ph.D, Justin Nice, Ph.D, Yujia Li, Ph.D, Christy Lau, Stephanie Adachi, Ciana Mora, Mafalda Cacciottolo, Ph.D, Kristi Elliott, Ph.D, Minghao Sun, Ph.D

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Nanograms of SARS-CoV-2 spike protein delivered by exosomes induce potent neutralization of both delta and omicron variants

Mafalda Cacciottolo, Yujia Li, Justin B. Nice, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun*

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Multivalent Exosome based protein vaccine: a “mix and match” approach to epidemic viruses’ challenges.

Mafalda Cacciottolo, Li-En Hsieh, Yujia Li, Michael J. LeClaire, Justin B Nice, Ryan Twaddle, Ciana Mora, Meredith Young, Jenna Angeles, Christy Lau, Cindy Jin, Kristi Elliott, Minghao Sun

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CaCl2 heatshock: A rapid, adjustable and feasible method for loading nucleic acid cargos in 293F exosomes

Mahrou Sadri, Michael LeClaire, Justin Nice, Mafalda Cacciottolo, Cindy Liu, Christy Lau, Stephanie Adachi, Firouz Mohsenian, Meena Murali, Kristi Elliott, Minghao Sun 

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Potency Assay Development for CAP-1002: An Allogeneic Cell Therapy in Phase 3 Clinical Trial for DMD

Minghao Sun, Kristi Elliott, Yujia Li, Lena Trinh, Firouz Mohsenian, Priya Mistry, Meena Murali, Stephanie Adachi, Esther Chin, Ben Canter, Arjang Salehi, Priyanka Ghorpade

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Exosomes engineered with SARS-CoV-2 spike and nucleocapsid proteins induce strong immune response against multiple variants of concern (VOCs)

Justin B Nice, Mafalda Cacciottolo, Yujia Li, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun 

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Exosome-Based Multivalent Vaccine: Achieving Potent Immunization, Broadened Reactivity, and Strong T-Cell Responses with Nanograms of Proteins

Mafalda Cacciottolo, Justin B Nice, Yujia Li, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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Multivalent Exosome based vaccine: a “cocktail” approach to epidemic viruses’ challenges

Mafalda Cacciottolo, LiEn Hsieh, Yujia Li, Justin B Nice, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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Exosome based multivalent vaccine: achieving potent immunization, broaden reactivity and T cell response with nanograms of proteins without any adjuvant

Mafalda Cacciottolo, Justin B Nice, Yujia Li, Michael J. LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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Exosome based multivalent vaccine: achieving potent immunization, broadened reactivity, and strong T cell responses with nanograms of proteins.

Mafalda Cacciottolo, Justin B Nice, Yujia Li, Michael J LeClaire, Ryan Twaddle, Ciana L. Mora, Stephanie Y. Adachi, Esther R. Chin, Meredith Young, Jenna Angeles, Kristi Elliott, Minghao Sun

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