With a clear focus on developing transformative therapies from bench to bedside, Capricor Therapeutics continues to drive forward preclinical and clinical research to investigate the products in its pipeline and their varied mechanism of actions.

View a list of current and archived publications related to Capricor’s research listed below according to investigational product.

CDCs (CAP-1002)

Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy (HOPE-2): a multicentre, randomized, double-blind, placebo-controlled, phase 2 trial

Craig M McDonald, Eduardo Marbán, Suzanne Hendrix, Nathaniel Hogan, Rachel Ruckdeschel Smith, Michelle Eagle, Richard S Finkel, Cuixia Tian, Joanne Janas, Matthew M Harmelink, Arun S Varadhachary, Michael D Taylor, Kan N Hor, Oscar H Mayer, Erik K Henricson, Pat Furlong, Deborah D Ascheim, Siegfried Rogy, Paula Williams, Linda Marbán, with the HOPE-2 Study Group* Lancet 2022; 399: 1049–58

Disease-modifying bioactivity of intravenous cardiosphere-derived cells and exosomes in mdx mice

Russell G. Rogers, Mario Fournier, Lizbeth Sanchez, Ahmed G. Ibrahim, Mark A. Aminzadeh, Michael I. Lewis, and Eduardo Marbán JCI Insight. 2019;4(7):e125754.

Intracoronary ALLogeneic heart STem cells to Achieve myocardial Regeneration (ALLSTAR): a randomized, placebo-controlled, double-blinded trial

Raj R Makkar, Dean J Kereiakes, Frank Aguirre, Glenn Kowalchuk, Tarun Chakravarty, Konstantinos Malliaras, Gary S Francis, Thomas J Povsic, Richard Schatz, Jay H Traverse, Janice M Pogoda, Rachel R Smith, Linda Marbán, Deborah D Ascheim, Mohammad R Ostovaneh, João A C Lima, Anthony DeMaria, Eduardo Marbán, Timothy D Henry

Allogeneic cardiosphere‑derived cells (CAP‑1002) in critically ill COVID‑19 patients: compassionate‑use case series

Siddharth Singh1, Tarun Chakravarty1, Peter Chen2, Akbarshakh Akhmerov1, Jeremy Falk2, Oren Friedman1,2, Tanzira Zaman2, Joseph E. Ebinger1, Mitch Gheorghiu1 · Linda Marbán3, Eduardo Marbán1, Raj R. Makkar1

MicroRNA composition delineates cardiosphere-derived cell and mesenchymal stem cell extracellular vesicles

Ann-Sophie Walravens1, Sasha Smolgovsky1, Liang Li1, Lauren Kelly1, Travis Antes1, Kiel Peck1, Tanner Quon, Linda Marbán, Benjamin Berman, Luis R. Borlado, Geoffrey de Couto

Allogeneic Cardiosphere-derived Cells for the Treatment of Heart Failure with Reduced Ejection Fraction: Results of the Dilated cardiomyopathy iNtervention with Allogeneic Myocardially-regeneratIve Cells (DYNAMIC) trial.

Chakravarty T, Henry TD, Kittleson M, Lima J, Siegel RJ, Slipczuk L, Pogoda JM, Smith RR, Malliaras K, Marbán L, Ascheim DD, Marbán E, Makkar RR. EuroIntervention 2019; Jaa-687 2019, doi: 10.4244/EIJ-D-19-00035

Cardiac and Skeletal Muscle Effects in the Randomized HOPE–Duchenne Trial

Michael Taylor, MD,* John Jefferies, MD,* Barry Byrne, MD, Joao Lima, MD, Bharath Ambale-Venkatesh, PhD, Mohammad R. Ostovaneh, MD, Raj Makkar, MD, Bryan Goldstein, MD, Rachel Ruckdeschel Smith, PhD,James Fudge, MD, Konstantinos Malliaras, MD, Brian Fedor, BS, Jeff Rudy, BS, Janice M. Pogoda, PhD, Linda Marb´an, PhD, Deborah D. Ascheim, MD, Eduardo Marb´an, MD, PhD, and Ronald G. Victor, MD Neurology 2019;92:e1-e13. doi:10.1212

Exosome-Mediated Benefits of Cell Therapy in Mouse and Human Models of Duchenne Muscular Dystrophy

Aminzadeh et al., Stem Cell Reports (2018)

Therapeutic benefits of intravenous cardiosphere-derived cell therapy in rats with pulmonary hypertension

Ryan C. Middleton1, Mario Fournier2, Xuan Xu2, Eduardo Marbán, Michael I. Lewis

Reversal of cardiac and skeletal manifestations of Duchenne muscular dystrophy by cardiosphere-derived cells and their exosomes in mdx dystrophic mice and in human Duchenne cardiomyocytes

Aminzadeh M, Rogers R, Gouin K, Fournier M, Tobin R, Guan X, Childers M, Andres A, Taylor D, Ibrahim A, Ding X, Torrente A, Goldhaber J, Victor R, Gottlieb R, Lewis M, Marbán E.

TCT-152 ALLogeneic Heart STem Cells To Achieve Myocardial Regeneration (ALLSTAR): The Six Month Phase I Safety Results.

Raj Makkar; Richard Schatz; Jay H. Traverse; Andrew Hamer; Katherine Beattie; Rachel R. Smith; Frances Kivel; Linda Marban; Eduardo Marban; Timothy D. Henry. J Am Coll Cardiol. 2014;64(11_S):. doi:10.1016/j.jacc.2014.07.18

Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice

Isotta Chimenti, Rachel Ruckdeschel Smith, Tao-Sheng Li, Gary Gerstenblith, Elisa Messina, Alessandro Giacomello, and Eduardo Marbán

TCT-152 ALLogeneic Heart STem Cells To Achieve Myocardial Regeneration (ALLSTAR): The Six Month Phase I Safety Results.

Raj Makkar; Richard Schatz; Jay H. Traverse; Andrew Hamer; Katherine Beattie; Rachel R. Smith; Frances Kivel; Linda Marban; Eduardo Marban; Timothy D. Henry. J Am Coll Cardiol. 2014;64(11_S):. doi:10.1016/j.jacc.2014.07.18

Abstract 20536: ALLogeneic Heart STem Cells to Achieve Myocardial Regeneration (ALLSTAR): the One Year Phase I Results.

Raj Makkar, Richard Schatz, Jay Traverse, Andrew Hamer, Katherine Beattie, Rachel R Smith, Francie Kivel, Linda Marbán, Eduardo Marbán, and Timothy D Henry.Circulation. 2014;130:A20536

Angiogenesis, cardiomyocyte proliferation and anti-fibrotic effects underlie structural preservation post-infarction by intramyocardially-injected cardiospheres.

Tseliou E, de Couto G, Terrovitis J, Sun B, Weixin L, Marbán L, Marbán E. PLoS One. 2014 Feb 18;9(2):e88590.

Human cardiosphere-derived cells from advanced heart failure patients exhibit augmented functional potency in myocardial repair.

Cheng K, Malliaras K, Smith RR, Shen D, Sun B, Blusztajn A, Xie Y, Ibrahim A, Aminzadeh MA, Liu W, Li TS, De Robertis MA, Marbán L, Czer LS, Trento A, Marbán E. JACC Heart Fail. 2014 Feb;2(1):49-61.

Moving beyond surrogate endpoints in cell therapy trials for heart disease.

Malliaras K, Marbán E. Stem Cells Transl Med. 2014 Jan;3(1):2-6.

Validation of contrast-enhanced magnetic resonance imaging to monitor regenerative efficacy after cell therapy in a porcine model of convalescent myocardial infarction.

Malliaras K, Smith RR, Kanazawa H, Yee K, Seinfeld J, Tseliou E, Dawkins JF, Kreke M, Cheng K, Luthringer D, Ho CS, Blusztajn A, Valle I, Chowdhury S, Makkar RR, Dharmakumar R, Li D, Marbán L, Marbán E. Circulation. 2013 Dec 24;128(25):2764-75.

Intracoronary cardiosphere-derived cells after myocardial infarction: evidence of therapeutic regeneration in the final 1-year results of the CADUCEUS trial (CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction).

Malliaras K, Makkar RR, Smith RR, Cheng K, Wu E, Bonow RO, Marbán L, Mendizabal A, Cingolani E, Johnston PV, Gerstenblith G, Schuleri KH, Lardo AC, Marbán E. J Am Coll Cardiol. 2014 Jan 21;63(2):110-22.

Allogeneic cardiospheres safely boost cardiac function and attenuate adverse remodeling after myocardial infarction in immunologically mismatched rat strains.

Tseliou E, Pollan S, Malliaras K, Terrovitis J, Sun B, Galang G, Marbán L, Luthringer D, Marbán E. J Am Coll Cardiol. 2013 Mar 12;61(10):1108-19.

Cardiomyocyte Proliferation and Progenitor Cell Recruitment Underlie Therapeutic Regeneration after Myocardial Infarction in the Adult Mouse Heart

Malliaras K, Zhang Y, Seinfeld J, Galang G, Tseliou E, Cheng K, Sun B, Aminzadeh M, Marbán E. EMBO Mol Med. 2013 Feb;5(2):191-209.

Brief report: Mechanism of extravasation of infused stem cells.

Cheng K, Shen D, Xie Y, Cingolani E, Malliaras K, Marbán E. Stem Cells. 2012 Dec;30(12):2835-42.

Functional performance of human cardiosphere-derived cells delivered in an in situ polymerizable hyaluronan-gelatin hydrogel

Cheng K, Blusztajn A, Shen D, Li TS, Sun B, Galang G, Zarembinski TI, Prestwich GD, Marban E, Smith RR, Marban L. Biomaterials. 2012 Jul;33(21):5317-24.

Magnetic enhancement of cell retention, engraftment, and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion.

Cheng K, Malliaras K, Li TS, Sun B, Houde C, Galang G, Smith J, Matsushita N, Marbán E. Cell Transplant. 2012;21(6):1121-35.

Direct Comparison of Different Stem Cell Types and Subpopulations Reveals Superior Paracrine Potency and Myocardial Repair Efficacy With Cardiosphere-Derived Cells

Li TS, Cheng K, Malliaras K, Smith RR, Zhang Y, Sun B, Matsushita N, Blusztajn A, Terrovitis J, Kusuoka H, Marban L, Marban E. J Am Coll Cardiol. 2012 Mar 6;59(10):942-53.

Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase I trial

Makkar RR, Smith RR, Cheng K, Malliaras K, Thomson LE, Berman D, Czer LS, Marban L, Mendizabal A, Johnston PV, Russell SD, Schuleri KH, Lardo AC, Gerstenblith G, Marban E. Lancet. 2012 Mar 10;379(9819):895-904.

Transplantation of platelet gel spiked with cardiosphere-derived cells boosts structural and functional benefits relative to gel transplantation alone in rats with myocardial infarction.

Cheng K, Shen D, Smith J, Galang G, Sun B, Zhang J, Marbán E. Biomaterials. 2012 Apr;33(10):2872-9.

Dose-dependent functional benefit of human cardiosphere transplantation in mice with acute myocardial infarction.

Shen D, Cheng K, Marbán E. J Cell Mol Med. 2012 Sep;16(9):2112-6.

Safety and efficacy of allogeneic cell therapy in infarcted rats transplanted with mismatched cardiosphere-derived cells.

Malliaras K, Li TS, Luthringer D, Terrovitis J, Cheng K, Chakravarty T, Galang G, Zhang Y, Schoenhoff F, Van Eyk J, Marbán L, Marbán E. Circulation. 2012 Jan 3;125(1):100-12.

Intrinsic cardiac origin of human cardiosphere-derived cells.

White AJ, Smith RR, Matsushita S, Chakravarty T, Czer LS, Burton K, Schwarz ER, Davis DR, Wang Q, Reinsmoen NL, Forrester JS, Marbán E, Makkar R. Eur Heart J. 2013 Jan;34(1):68-75.

Cardiac cell therapy: where we’ve been, where we are, and where we should be headed

Malliaras K, Marban E. Br Med Bull. 2011;98:161-85.

Intramyocardial injection of autologous cardiospheres or cardiosphere-derived cells preserves function and minimizes adverse ventricular remodeling in pigs with heart failure post-myocardial infarction.

Lee ST, White AJ, Matsushita S, Malliaras K, Steenbergen C, Zhang Y, Li TS, Terrovitis J, Yee K, Simsir S, Makkar R, Marbán E. J Am Coll Cardiol. 2011 Jan 25;57(4):455-65.

Cardiospheres Recapitulate a Niche-Like Microenvironment Rich in Stemness and Cell-Matrix Interactions, Rationalizing their Enhanced Functional Potency for Myocardial Repair.

Li TS, Cheng K, Lee ST, Matsushita S, Davis D, Malliaras K, Zhang Y, Matsushita N, Ruckdeshel Smith R, Marban E. Stem Cells. 2010 Nov;28(11):2088-98.

Dedifferentiation and proliferation of mammalian cardiomyocytes

Zhang Y, Li TS, Lee ST, Wawrowsky KA, Cheng K, Galang G, Malliaras K, Abraham MR, Wang C, Marban E. PLoS One. 2010 Sep 3;5(9):e12559.

Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair

Li TS, Cheng K, Malliaras K, Matsushita N, Sun B, Marban L, Zhang Y, Marban E. Cardiovasc Res. 2010 Aug 21.

Physiological levels of reactive oxygen species are required to maintain genomic stability in stem cells.

Stem Cells. 2010 Jul;28(7):1178-85.

Magnetic targeting enhances engraftment and functional benefit of iron-labeled cardiosphere-derived cells in myocardial infarction

Cheng K, Li TS, Malliaras K, Davis DR, Zhang Y, Marban E. Circ Res. 2010 May 28;106(10):1570-81.

Human cardiospheres are a source of stem cells with cardiomyogenic potential.

Davis DR, Ruckdeschel Smith R, Marban E. Stem Cells. 2010 May;28(5):903-4.

Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies

Davis DR, Kizana E, Terrovitis J, Barth AS, Zhang Y, Smith RR, Miake J, Marban E. J Mol Cell Cardiol. 2010 Aug;49(2):312-21.

Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice

Chimenti I, Smith RR, Li TS, Gerstenblith G, Messina E, Giacomello A, Marban E. Circ Res. 2010 Mar 19;106(5):971-80.

Noninvasive quantification and optimization of acute cell retention by in vivo positron emission tomography after intramyocardial cardiac-derived stem cell delivery

Terrovitis J, Lautamäki R, Bonios M, Fox J, Engles JM, Yu J, Leppo MK, Pomper MG, Wahl RL, Seidel J, Tsui BM, Bengel FM, Abraham MR, Marban E. J Am Coll Cardiol. 2009 Oct 20;54(17):1619-26.

Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue

Davis DR, Zhang Y, Smith RR, Cheng K, Terrovitis J, Malliaras K, Li TS, White A, Makkar R, Marban E. PLoS One. 2009 Sep 25;4(9):e7195.

Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy

Johnston PV, Sasano T, Mills K, Evers R, Lee ST, Smith RR, Lardo AC, Lai S, Steenbergen C, Gerstenblith G, Lange R, Marban E. Circulation. 2009 Sep 22; 120(12):1075-83, 7 p following 1083. Epub 2009 Sep 8.

Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart.

Terrovitis J, Stuber M, Youssef A, Preece S, Leppo M, Kizana E, Schär M, Gerstenblith G, Weiss RG, Marbán E, Abraham MR. Circulation. 2008 Mar 25;117(12):1555-62.

Regenerative potential of cardiosphere-derived cells expanded from percutaneous endomyocardial biopsy specimens

Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, Giacomello A, Abraham MR, Marban E. Circulation. 2007 Feb 20;115(7):896-908. Epub 2007 Feb 5.

Isolation and expansion of adult cardiac stem cells from human and murine heart.

Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F, Salio M, Battaglia M, Latronico MV, Coletta M, Vivarelli E, Frati L, Cossu G, Giacomello A. Circ Res. 2004 Oct 29;95(9):911-21. Epub 2004 Oct 7.


Exosome-mediated mRNA Delivery in vivo is safe and can be used to induce SARS-CoV-2 immunity

Shang Jui Tsai, Nadia A. Atai, Mafalda Cacciottolo, Justin Nice, Arjang Salehi, Chenxu Guo, Alanna Sedgwick, Saravana Kanagavelu, Stephen J. Gould; Journal of Biological Chemistry: Accepted Date: 28 September 2021

Extracellular Vesicles Derived from Cardiosphere-derived Cells as a Potential Antishock Therapeutic

Chance, Tiffani C. PhD; Wu, Xiaowu MD; Keesee, Jeffrey D. BS; Garcia-Marcano, Josue; Salgado, Christi L. BS; Liu, Bin BS; Moseley, Jennifer J. PhD; Peck, Kiel A. MS; R.-Borlado, Luis PhD; Atai, Nadia A. MD, PhD; Gould, Stephen J. PhD; Marban, Linda S. PhD; Cap, Andrew P. MD, PhD; Rathbone, Christopher R. PhD; Bynum, James A. PhD; Journal of Trauma and Acute Care Surgery: August 2021 – Volume 91 – Issue 2S – p S81-S88 doi: 10.1097/TA.0000000000003218

Exosome-Mediated mRNA Delivery For SARS-CoV-2 Vaccination

Shang Jui Tsai, Chenxu Guo, Alanna Sedgwick, Saravana Kanagavelu, Justin Nice,
Sanjana Shetty,Connie Landaverde, Nadia A. Atai, and Stephen J. Gould :doi:;

Small molecule inhibitors and culture conditions enhance therapeutic cell and EV potency via activation of beta-catenin and suppression of THY1

Ahmed Gamal-EldinIbrahim Ph.D., MPH, Chang Li BS, Alessandra Ciullo Ph.D. K. Candis Jones-Ungerleider MD, MSE, Kiel Peck BS, Linda Marbán Ph.D, Eduardo Marbán MD, Ph.D., Nanotechnology, Biology and Medicine, Volume 33,(2021)

The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike

Chenxu Guo, Shang-Jui Tsai, Yiwei Ai, Maggie Li, Andrew Pekosz, Andrea Cox, Nadia Atai, Stephen J. Gould, doi: (2020)

Exosome-Mediated mRNA Delivery For SARS-CoV-2 Vaccination

Shang-Jui Tsai, Chenxu Guo, Nadia A. Atai, and Stephen J. Gould, BioRxiv (2020)

Augmenting canonical Wnt signalling in therapeutically inert cells converts them into therapeutically potent exosome factories.

Ahmed G. E. Ibrahim, Chang Li, Russel Rogers, Mario Fournier, Liang Li, Sharon D. Vaturi, Travis Antes, Lizbeth Sanchez, Akbarshakh Akhmerov, Jennifer Johnson Moseley, Brooke Tobin, Luis Rodriguez-Borlado, Rachel R. Smith, Linda Marbán & Eduardo Marbán , Nature Biomedical Engineering (2019)

Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction

Romain Gallet, JamesDawkins, Jackelyn Valle, Eli Simsolo, Geoffrey de Couto, Ryan Middleton, EleniTseliou, Daniel Luthringer, Michelle Kreke, Rachel R. Smith, Linda Marbán, Bijan Ghaleh, and Eduardo Marbán

Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL-10 expression and secretion

Linda Cambier, Geoffrey de Couto, Ahmed Ibrahim, Antonio K Echavez, Jackelyn Valle,
Weixin Liu, Michelle Kreke, Rachel R Smith, Linda Marbán & Eduardo Marbán

A Comprehensive Method for Identification of Suitable Reference Genes in
Extracellular Vesicles

Kenneth Gouina, Kiel Peck, Travis Antes, Jennifer Leigh Johnson, Chang Li, Sharon Denise Vaturi, Ryan Middleton, Geoff de Couto, Ann-Sophie Walravens, Luis Rodriguez-Borlado, Rachel Ruckdeschel Smith, Linda Marbán, Eduardo Marbán and Ahmed Gamal-Eldin Ibrahim

Macrophages Mediate Cardioprotective Cellular Postconditioning in Acute Myocardial Infarction

Geoffrey de Couto, Weixin Liu, Eleni Tseliou, Baiming Sun, Nupur Makkar, Hideaki Kanazawa,
Moshe Arditi, and Eduardo Marbán

Commercial Potential as Byproducts of Cell Manufacturing for Research and Therapeutic Use

James A. Smith, Kelvin S. Ng, Benjamin E. Mead, Sue Dopson, Brock Reeve, James Edwards, Matthew J.A. Wood, Andrew J. Carr, Kim Bure, Jeffrey M. Karp, and David A. Brindley

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy.

Ibrahim A, Cheng K, Marban E. Stem Cell Reports. 2014 May;2(5): 606-619.